hypoxia-inducible factor 1, alpha subunit | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | HIF1A | ||||||
NCBI gene | 3091 | ||||||
HGNC | 4910 | ||||||
OMIM | 603348 | ||||||
RefSeq | NM_001530 | ||||||
UniProt | Q16665 | ||||||
Other data | |||||||
Locus | Chr. 14 q21-q24 | ||||||
|
aryl hydrocarbon receptor nuclear translocator | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | ARNT | ||||||
Alt. symbols | HIF1B, bHLHe2 | ||||||
NCBI gene | 405 | ||||||
HGNC | 700 | ||||||
OMIM | 126110 | ||||||
RefSeq | NM_001668 | ||||||
UniProt | P27540 | ||||||
Other data | |||||||
Locus | Chr. 1 q21 | ||||||
|
endothelial PAS domain protein 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | EPAS1 | ||||||
Alt. symbols | HIF2A, MOP2, PASD2, HLF | ||||||
NCBI gene | 2034 | ||||||
HGNC | 3374 | ||||||
OMIM | 603349 | ||||||
RefSeq | NM_001430 | ||||||
UniProt | Q99814 | ||||||
Other data | |||||||
Locus | Chr. 2 p21-p16 | ||||||
|
aryl-hydrocarbon receptor nuclear translocator 2 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | ARNT2 | ||||||
Alt. symbols | HIF2B, KIAA0307, bHLHe1 | ||||||
NCBI gene | 9915 | ||||||
HGNC | 16876 | ||||||
OMIM | 606036 | ||||||
RefSeq | NM_014862 | ||||||
UniProt | Q9HBZ2 | ||||||
Other data | |||||||
Locus | Chr. 1 q24 | ||||||
|
hypoxia-inducible factor 3, alpha subunit | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | HIF3A | ||||||
NCBI gene | 64344 | ||||||
HGNC | 15825 | ||||||
OMIM | 609976 | ||||||
RefSeq | NM_152794 | ||||||
UniProt | Q9Y2N7 | ||||||
Other data | |||||||
Locus | Chr. 19 q13 | ||||||
|
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.[1][2] They also respond to instances of pseudohypoxia, such as thiamine deficiency.[3][4] Both hypoxia and pseudohypoxia leads to impairment of adenosine triphosphate (ATP) production by the mitochondria.
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