Back عوامل محفزة لنقص الأكسجين Arabic Hypoxie-induzierter Faktor German Factor inducible por hipoxia Spanish Hypoksian indusoima tekijä Finnish Facteur induit par l'hypoxie French Hypoxia-inducible factor Italian 低酸素誘導因子 Japanese 저산소증 유도인자 Korean Czynnik indukowany hipoksją 1 Polish Факторы, индуцируемые гипоксией Russian
| hypoxia-inducible factor 1, alpha subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | HIF1A | ||||||
| NCBI gene | 3091 | ||||||
| HGNC | 4910 | ||||||
| OMIM | 603348 | ||||||
| RefSeq | NM_001530 | ||||||
| UniProt | Q16665 | ||||||
| Other data | |||||||
| Locus | Chr. 14 q21-q24 | ||||||
| |||||||
| aryl hydrocarbon receptor nuclear translocator | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARNT | ||||||
| Alt. symbols | HIF1B, bHLHe2 | ||||||
| NCBI gene | 405 | ||||||
| HGNC | 700 | ||||||
| OMIM | 126110 | ||||||
| RefSeq | NM_001668 | ||||||
| UniProt | P27540 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q21 | ||||||
| |||||||
| endothelial PAS domain protein 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EPAS1 | ||||||
| Alt. symbols | HIF2A, MOP2, PASD2, HLF | ||||||
| NCBI gene | 2034 | ||||||
| HGNC | 3374 | ||||||
| OMIM | 603349 | ||||||
| RefSeq | NM_001430 | ||||||
| UniProt | Q99814 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p21-p16 | ||||||
| |||||||
| aryl-hydrocarbon receptor nuclear translocator 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARNT2 | ||||||
| Alt. symbols | HIF2B, KIAA0307, bHLHe1 | ||||||
| NCBI gene | 9915 | ||||||
| HGNC | 16876 | ||||||
| OMIM | 606036 | ||||||
| RefSeq | NM_014862 | ||||||
| UniProt | Q9HBZ2 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q24 | ||||||
| |||||||
| hypoxia-inducible factor 3, alpha subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | HIF3A | ||||||
| NCBI gene | 64344 | ||||||
| HGNC | 15825 | ||||||
| OMIM | 609976 | ||||||
| RefSeq | NM_152794 | ||||||
| UniProt | Q9Y2N7 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13 | ||||||
| |||||||
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.[1][2] They also respond to instances of pseudohypoxia, such as thiamine deficiency.[3][4] Both hypoxia and pseudohypoxia leads to impairment of adenosine triphosphate (ATP) production by the mitochondria.
- ^ Smith TG, Robbins PA, Ratcliffe PJ (May 2008). "The human side of hypoxia-inducible factor". British Journal of Haematology. 141 (3): 325–34. doi:10.1111/j.1365-2141.2008.07029.x. PMC 2408651. PMID 18410568.
- ^ Wilkins SE, Abboud MI, Hancock RL, Schofield CJ (April 2016). "Targeting Protein-Protein Interactions in the HIF System". ChemMedChem. 11 (8): 773–86. doi:10.1002/cmdc.201600012. PMC 4848768. PMID 26997519.
- ^ Rl S, Ja Z (2013). "HIF1-α-mediated gene expression induced by vitamin B1 deficiency". International Journal for Vitamin and Nutrition Research. 83 (3): 188–197. doi:10.1024/0300-9831/a000159. ISSN 0300-9831. PMID 24846908.
- ^ C M, D L (2021-09-29). "Hiding in Plain Sight: Modern Thiamine Deficiency". Cells. 10 (10): 2595. doi:10.3390/cells10102595. ISSN 2073-4409. PMC 8533683. PMID 34685573.
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